Myrtle Campbell grew up in Columbus Nebraska and graduated from the local high school before receiving a diploma from the teacher training division in 1910. That same year, she began working as an art supervisor until her marriage to Walter Campbell in 1915.
The young family moved around several times before settling in Boulder, Colorado where Walter worked as a professor at University of Colorado. Mrytle worked at the college as an art professor during the summers from 1935-1937.
Campbell became a serious painter in the mid 1920's and produced many works over the years. Her trademarks were Colorado's mountain towns, its gold and coal mines and mills, and high peaks and streams. She regularly went on trips to various locations, where she made quick sketches before returning to her studio to develop them into finished works.
She was a longtime exhibitor with the Boulder Artists Guild, which she co-founded. She held one person exhibitions at the University of Colorado, Boulder; Denver Art Museum; and Colorado Women's College, Denver.
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